PA Paine is a specialist registrar and research fellow in gastroenterology on the North-Western scheme based in Manchester. W Rees is a consultant gastroenterologist and the clinical director of gastroenterology at Hope Hospital with interests in endoscopy, peptic ulcer, and inflammatory bowel disease. C Babbs is a consultant gastroenterologist with interests in therapeutic endoscopy and hepato-biliary disease. JL Shaffer is a consultant gastroenterologist and head of the intestinal failure unit. G Armstrong is a consultant in cellular pathology with a special interest in gastrointestinal disease. H Burnett is a consultant radiologist with a special interest in gastrointestinal disorders. Q Aziz is professor and head of the visceral pain group at the University of Manchester. He has a major interest in the gut-brain axis and its dysfunction.