3 hours 30 minutes
Other healthcare professionals
Therapeutic drug monitoring as a tool for therapy optimisation
At the completion of this activity, the participant will be able to:
- Recognise characteristics of drugs that make them good candidates for TDM
- Describe appropriate indications for TDM
- Understand the factors that may affect measured concentrations
- List and discuss the importance of information needed when requesting drug concentration
- Interpret measured drug concentrations
- Adjust dose based on TDM
- Apply basic concept of clinical pharmacokinetics to TDM
- Understand indications for TDM
- Understand the importance of time sampling
- Understand factors that might affect drug concentrations
- Describe analytical needs for therapeutic drug monitoring
- Understand the importance of pharmacogenomics biomarkers
- Understand the importance of genetic factors in the response to drugs
- Describe a pharmacokinetic model for a drug using terms of Volume of distribution, elimination rate constant, renal clearance
- Explain the error and residual error in the used population model
- Describe the pharmaconynamic properties of beta lactam antibiotics
- Describe the pharmacodynamic properties of aminoglycoside antibiotics
- Describe the pharmacodynamic properties of the fluoroquinolone antibiotics
- Explain why and how TDM should be used in psychiatry and neurology
- Differentiate between therapeutic and dose related reference ranges
- Explain how genotyping may be combined with TDM
- Use TDM for identification of pharmacokinetic abnormalities
- Understand basic clinical pharmacokinetics of oncolytics and immunosuppressants
- Comprehend the rationale for TDM of oncolytics and immunosuppressants
- Understand that TDM software tools affect efficiency not effectiveness
- Understand the interaction between TDM processes, people and tools
- Gain insight in how software tools support the TDM process cycle
- Understand the key components of TDM software tools
- Evaluate TDM software tools current available on the market (long/short list)
- Assess the need for dose adjustment
- Adjust the dose of drugs based on the results of TDM
- Interpret measured drug concentration
- Develop a Plan for therapeutic drug monitoring
- Provide TDM service
- Know how population pharmacokinetic models are developed
- Know how population pharmacinetic values are calculated into individual values
- Interprete drug concentrations in blood and give recommendations for clinical decision making
- Give recommendations in case of adverse drug reactions
- Find out if low drug concentrations are due to poor adherence or due to rapid clearance
- Decide if the dose should be maintained in spite of high drug concentrations
- Understand current TDM concepts of oncolytic and immunosuppressive agents
- Implement TDM of oncolytics and immunosuppressants
- Interpret measured drug concentrations based on patient's characteristics
- Understand the need for dose adjustment
- Describe the difficulties and solutions for the implementation of a TDM program in an environment of scarce resources
- Describe, present and discuss a business plan to implement such a program in their own hospital setting.
Modules in this course
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Contributors:
Branislava Miljković, Azucena Aldaz, Kees Neef, Daniel J. Touw....
Accreditation
Accreditor | credit | Accreditation statement |
---|---|---|
BMJ and EAHP: Therapeutic drug monitoring | 0.54 credits, 3:30 hours | This course (Therapeutic drug monitoring as a tool for therapy optimisation) is accredited to the combined value of the modules it contains. |
Release date
22 Jul 2019