• Course

3 hours 30 minutes

Other healthcare professionals

Therapeutic drug monitoring as a tool for therapy optimisation

At the completion of this activity, the participant will be able to:

  • Recognise characteristics of drugs that make them good candidates for TDM
  • Describe appropriate indications for TDM
  • Understand the factors that may affect measured concentrations
  • List and discuss the importance of information needed when requesting drug concentration
  • Interpret measured drug concentrations
  • Adjust dose based on TDM
  • Apply basic concept of clinical pharmacokinetics to TDM
  • Understand indications for TDM
  • Understand the importance of time sampling
  • Understand factors that might affect drug concentrations
  • Describe analytical needs for therapeutic drug monitoring
  • Understand the importance of pharmacogenomics biomarkers
  • Understand the importance of genetic factors in the response to drugs
  • Describe a pharmacokinetic model for a drug using terms of Volume of distribution, elimination rate constant, renal clearance
  • Explain the error and residual error in the used population model
  • Describe the pharmaconynamic properties of beta lactam antibiotics
  • Describe the pharmacodynamic properties of aminoglycoside antibiotics
  • Describe the pharmacodynamic properties of the fluoroquinolone antibiotics
  • Explain why and how TDM should be used in psychiatry and neurology
  • Differentiate between therapeutic and dose related reference ranges
  • Explain how genotyping may be combined with TDM
  • Use TDM for identification of pharmacokinetic abnormalities
  • Understand basic clinical pharmacokinetics of oncolytics and immunosuppressants
  • Comprehend the rationale for TDM of oncolytics and immunosuppressants
  • Understand that TDM software tools affect efficiency not effectiveness
  • Understand the interaction between TDM processes, people and tools
  • Gain insight in how software tools support the TDM process cycle
  • Understand the key components of TDM software tools
  • Evaluate TDM software tools current available on the market (long/short list)
  • Assess the need for dose adjustment
  • Adjust the dose of drugs based on the results of TDM
  • Interpret measured drug concentration
  • Develop a Plan for therapeutic drug monitoring
  • Provide TDM service
  • Know how population pharmacokinetic models are developed
  • Know how population pharmacinetic values are calculated into individual values
  • Interprete drug concentrations in blood and give recommendations for clinical decision making
  • Give recommendations in case of adverse drug reactions
  • Find out if low drug concentrations are due to poor adherence or due to rapid clearance
  • Decide if the dose should be maintained in spite of high drug concentrations
  • Understand current TDM concepts of oncolytic and immunosuppressive agents
  • Implement TDM of oncolytics and immunosuppressants
  • Interpret measured drug concentrations based on patient's characteristics
  • Understand the need for dose adjustment
  • Describe the difficulties and solutions for the implementation of a TDM program in an environment of scarce resources
  • Describe, present and discuss a business plan to implement such a program in their own hospital setting.

Contributors:

Branislava Miljković, Azucena Aldaz, Kees Neef, Daniel J. Touw....

Accreditation

Accreditor credit Accreditation statement
BMJ and EAHP: Therapeutic drug monitoring 0.54 credits, 3:30 hours This course (Therapeutic drug monitoring as a tool for therapy optimisation) is accredited to the combined value of the modules it contains.

Release date

22 Jul 2019